منابع مشابه
Molecular mechanisms of axon growth and guidance.
PROTEINS THAT PROMOTE NEURITE OUTGROWTH ............................................................ 119 Soh~ble Neurotrophic Agents .................................................................................... 122 ECM Proteins .......................................................................................................... 123 CAMs .................................................
متن کاملAxon guidance by growth-rate modulation.
Guidance of axons by molecular gradients is crucial for wiring up the developing nervous system. It often is assumed that the unique signature of such guidance is immediate and biased turning of the axon tip toward or away from the gradient. However, here we show that such turning is not required for guidance. Rather, by a combination of experimental and computational analyses, we demonstrate t...
متن کاملMolecular gradients along the proximal-distal axis of embryonic insect legs: possible guidance cues of pioneer axon growth.
It has been proposed that gradients of environmental cues direct the proximal growth of pioneer axons in embryonic insect legs. Hybridoma techniques have been used to produce 3 monoclonal antibodies (mAbs) that bind to components associated with the basal lamina/extracellular matrix that are non-uniformly distributed along the proximal-distal axis of cockroach legs at the time of pioneer axon g...
متن کاملAxon guidance
The nervous system has the job of controlling and monitoring events throughout the whole body. But, unlike endocrine cells, which control their targets through long-range chemical cues, neurons communicate through direct cellular contacts, or synapses. As the information content of the electrical signals used by neurons is limited, much of the meaning in neural communication is conveyed by the ...
متن کاملCommon mechanisms underlying growth cone guidance and axon branching.
During development, growth cones direct growing axons into appropriate targets. However, in some cortical pathways target innervation occurs through the development of collateral branches that extend interstitially from the axon shaft. How do such branches form? Direct observations of living cortical brain slices revealed that growth cones of callosal axons pause for many hours beneath their co...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 1997
ISSN: 0012-1606
DOI: 10.1006/dbio.1997.8704